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Sodium Chloride [3%]

Fundacion Clinica Valle del Lili · FDA-approved active Small molecule

Sodium chloride 3% is a hypertonic saline solution that draws fluid from intracellular and interstitial spaces into the vascular compartment through osmotic gradient.

Sodium chloride 3% is a hypertonic saline solution that draws fluid from intracellular and interstitial spaces into the vascular compartment through osmotic gradient. Used for Hyponatremia (symptomatic or severe), Cerebral edema and increased intracranial pressure, Acute volume expansion in critical care.

At a glance

Generic nameSodium Chloride [3%]
Also known asHypertonic Saline Solution, NaCl
SponsorFundacion Clinica Valle del Lili
Drug classElectrolyte solution / Osmotic agent
ModalitySmall molecule
Therapeutic areaCritical Care / Acute Medicine
PhaseFDA-approved

Mechanism of action

The 3% concentration creates an osmotic gradient that pulls water from tissues into the bloodstream, increasing intravascular volume and plasma osmolality. This mechanism is used to treat hyponatremia (low serum sodium) and cerebral edema by reducing intracranial pressure through fluid redistribution. It is also used for volume expansion in acute care settings.

Approved indications

Common side effects

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