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Sodium Bicarbonate Solution
Sodium bicarbonate neutralizes excess acid in the body by acting as a buffer to increase blood and urine pH.
Sodium bicarbonate neutralizes excess acid in the body by acting as a buffer to increase blood and urine pH. Used for Metabolic acidosis, Urinary alkalinization, Antacid for gastric hyperacidity.
At a glance
| Generic name | Sodium Bicarbonate Solution |
|---|---|
| Also known as | Isotonic Sodium Bicarbonate, Sodibic capsules (Aspen Australia, NSW, Australia), HCO3, 154 mEq/L in dextrose and H2O, Sodium Bicarbonate |
| Sponsor | VA Greater Los Angeles Healthcare System |
| Drug class | Alkalinizing agent |
| Modality | Small molecule |
| Therapeutic area | General/Supportive Care |
| Phase | FDA-approved |
Mechanism of action
Sodium bicarbonate is a weak base that reacts with hydrogen ions to form water and carbon dioxide, thereby reducing systemic acidosis. It is commonly used to treat metabolic acidosis, alkalinize urine for certain drug overdoses or kidney stone prevention, and manage acid-base imbalances in clinical settings.
Approved indications
- Metabolic acidosis
- Urinary alkalinization
- Antacid for gastric hyperacidity
- Supportive care in renal failure and certain drug overdoses
Common side effects
- Metabolic alkalosis
- Hypernatremia
- Hypokalemia
- Fluid overload
- Nausea
Key clinical trials
- SODium BICarbonate for Metabolic Acidosis in the ICU (PHASE3)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates (NA)
- Prevention of Oral Mucositis in Head and Neck Cancer. (NA)
- Use of Preoperative Sodium Bicarbonate Among Women With Obstructed Labor (PHASE3)
- Evaluating the Clinical Effectiveness of Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury (PHASE4)
- Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sodium Bicarbonate Solution CI brief — competitive landscape report
- Sodium Bicarbonate Solution updates RSS · CI watch RSS
- VA Greater Los Angeles Healthcare System portfolio CI