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Sodium Bicarbonate and Sodium chloride

University Hospital, Clermont-Ferrand · FDA-approved active Small molecule

Sodium bicarbonate neutralizes gastric acid and raises blood pH, while sodium chloride provides essential electrolyte replacement and osmotic balance.

Sodium bicarbonate neutralizes gastric acid and raises blood pH, while sodium chloride provides essential electrolyte replacement and osmotic balance. Used for Metabolic acidosis correction, Gastric acid neutralization, Electrolyte replacement in fluid resuscitation.

At a glance

Generic nameSodium Bicarbonate and Sodium chloride
SponsorUniversity Hospital, Clermont-Ferrand
Drug classElectrolyte and antacid combination
ModalitySmall molecule
Therapeutic areaGastroenterology, Emergency Medicine, Nephrology
PhaseFDA-approved

Mechanism of action

Sodium bicarbonate acts as a buffer to neutralize hydrochloric acid in the stomach and correct metabolic acidosis by increasing serum bicarbonate levels. Sodium chloride restores electrolyte balance and maintains osmotic pressure, particularly important in fluid resuscitation and electrolyte depletion scenarios. Together, this combination addresses both acid-base disturbances and electrolyte imbalances.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results