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Ammonul (SODIUM BENZOATE)
Ammonul works by inhibiting the enzyme carbonic anhydrase 2, which helps to reduce ammonia levels in the body.
Ammonul (Sodium Benzoate) is a small molecule drug that targets carbonic anhydrase 2. It is a sodium benzoate drug class, FDA approved in 1987 for the treatment of apnea in the newborn and hyperammonemia. The commercial status of Ammonul is not publicly available. Key safety considerations include the potential for adverse effects, although specific details are not provided. As a sodium benzoate, it is a generic drug class.
At a glance
| Generic name | SODIUM BENZOATE |
|---|---|
| Drug class | sodium benzoate |
| Target | Carbonic anhydrase 2 |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
| First approval | 1987 |
Mechanism of action
Think of ammonia like a toxic gas in your body. Carbonic anhydrase 2 helps to make more ammonia. Ammonul blocks this enzyme, so less ammonia is made, which can help treat conditions like hyperammonemia.
Approved indications
- Apnea in the newborn
- Hyperammonemia
Common side effects
- Creatinine renal clearance decreased
- Sedation complication
- Blood calcium decreased
- Orthostatic hypotension
- Cognitive disorder
- Hyperammonaemia
- Depressed level of consciousness
- Balance disorder
- Mobility decreased
- Constipation
Key clinical trials
- The Dose Finding Study of DAOIB Added to tDCS for AD (PHASE2)
- Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3 (PHASE4)
- Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention (PHASE2)
- A Trial of Shengmai Liquid for Long COVID Fatigue. (PHASE4)
- Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes (PHASE1,PHASE2)
- Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (PHASE4)
- Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
- Caveolin-1 and Vascular Dysfunction (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ammonul CI brief — competitive landscape report
- Ammonul updates RSS · CI watch RSS