Last reviewed 2026-05-13 · How we verify

Sodium < 1mEq/kg/day

Sodium restriction at <1mEq/kg/day reduces total body sodium content to manage fluid balance and electrolyte homeostasis.

Sodium restriction at <1mEq/kg/day reduces total body sodium content to manage fluid balance and electrolyte homeostasis. Used for Fluid overload management in pediatric patients, Heart failure in children, Chronic kidney disease with sodium retention.

At a glance

Mechanism of action

This is a dietary sodium restriction protocol rather than a pharmacological drug. It limits daily sodium intake to less than 1 milliequivalent per kilogram of body weight, which reduces extracellular fluid volume and helps manage conditions characterized by sodium and fluid retention. This approach is commonly used in pediatric patients with conditions such as heart failure, renal disease, or hypertension.

Approved indications

• Fluid overload management in pediatric patients
• Heart failure in children
• Chronic kidney disease with sodium retention
• Hypertension management in pediatric populations

Common side effects

• Hyponatremia
• Nutritional deficiency if overly restrictive
• Palatability issues and dietary non-adherence

Key clinical trials

• Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD (PHASE2)
• Early Sodium Intake in Preterm Newborns (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Sodium < 1mEq/kg/day CI brief — competitive landscape report
• Sodium < 1mEq/kg/day updates RSS · CI watch RSS
• Hospital del Niño "Dr. Federico Gomez Santos" portfolio CI