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SnF
SnF (stannous fluoride) strengthens tooth enamel and reduces cavity formation by promoting remineralization and providing fluoride ions that harden the tooth surface.
SnF (stannous fluoride) strengthens tooth enamel and reduces cavity formation by promoting remineralization and providing fluoride ions that harden the tooth surface. Used for Dental caries prevention, Gingivitis reduction, Enamel remineralization.
At a glance
| Generic name | SnF |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Topical fluoride agent |
| Target | Tooth enamel (hydroxyapatite); oral bacteria |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Stannous fluoride is a topical fluoride compound that works through two mechanisms: the fluoride ion enhances remineralization of early enamel lesions and increases enamel resistance to acid attack, while the stannous ion provides antimicrobial activity against cariogenic bacteria. This combination reduces the incidence of dental caries and gingivitis when used in toothpastes or rinses.
Approved indications
- Dental caries prevention
- Gingivitis reduction
- Enamel remineralization
Common side effects
- Tooth staining
- Mild gingival irritation
- Unpleasant taste
Key clinical trials
- Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion (PHASE3)
- Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses. (PHASE4)
- Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis. (PHASE3)
- Dentinal Hypersensitivity Reduction (PHASE3)
- Skilled Nursing Facility at Home Trial (NA)
- Evaluation of a Stannous Fluoride Dentifrice for Control of Oral Malodor (NA)
- Intra Oral Application (IOA) Testing Study of a Stannous Toothpaste (NA)
- Dental Plaque Prevention Efficacy of a Stannous Fluoride Toothpaste (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SnF CI brief — competitive landscape report
- SnF updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI