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Smartject Device delivery of Golimumab

Merck Sharp & Dohme LLC · FDA-approved active Small molecule

Golimumab is a monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling.

Golimumab is a monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling. Used for Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis.

At a glance

Generic nameSmartject Device delivery of Golimumab
SponsorMerck Sharp & Dohme LLC
Drug classTNF-α inhibitor (monoclonal antibody)
TargetTNF-α (Tumor Necrosis Factor-alpha)
ModalitySmall molecule
Therapeutic areaImmunology
PhaseFDA-approved

Mechanism of action

Golimumab is a fully human monoclonal antibody that targets TNF-α, a key pro-inflammatory cytokine involved in autoimmune and inflammatory diseases. By blocking TNF-α, it suppresses the inflammatory cascade and reduces immune-mediated tissue damage. The Smartject device is an auto-injector delivery system that enables patient self-administration of the drug.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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