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Skin allograft
A skin allograft is a transplanted human skin tissue from a donor that provides temporary or permanent coverage and biological functions to damaged or missing skin.
A skin allograft is a transplanted human skin tissue from a donor that provides temporary or permanent coverage and biological functions to damaged or missing skin. Used for Severe burns, Chronic wounds, Traumatic skin injuries.
At a glance
| Generic name | Skin allograft |
|---|---|
| Sponsor | Virginia Commonwealth University |
| Drug class | Tissue allograft |
| Modality | Biologic |
| Therapeutic area | Dermatology / Wound Care / Regenerative Medicine |
| Phase | FDA-approved |
Mechanism of action
Skin allografts are cadaveric or living donor skin grafts that restore the barrier function, reduce infection risk, and promote healing of severe burns, chronic wounds, or traumatic injuries. The graft integrates with the recipient's tissue and can provide both structural support and biological signaling to facilitate wound healing and tissue regeneration.
Approved indications
- Severe burns
- Chronic wounds
- Traumatic skin injuries
- Surgical wound coverage
Common side effects
- Graft rejection
- Infection
- Graft failure/non-take
- Scarring
Key clinical trials
- GMEB-SASS: A Gene-Modified Skin Substitute for RDEB Treatment (PHASE1, PHASE2)
- Randomized Controlled Trial to Investigate Clinical Outcomes and Associated Costs When PermeaDerm is Used as Temporary Dressing for Surgical Wounds (NA)
- Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers (NA)
- Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs (NA)
- Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease (NA)
- Assessment of Safety and Effectiveness of NovoSorb® BTM in Severe Burns (NA)
- Use of Allograft Adipose Matrix for Small Joint Arthritis of the Hand (EARLY_PHASE1)
- HEAL-4: Real-World Effectiveness of 4 Amniotic Allografts Adjunctive to Standard Care in DFU, VLU, and PU
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |