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Sevoflurane/Ultane
Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling. Used for Induction and maintenance of general anesthesia in adults and pediatric patients.
At a glance
| Generic name | Sevoflurane/Ultane |
|---|---|
| Also known as | Sevoflurane/ Ultane 250mL/Bot |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital |
| Drug class | Volatile general anesthetic |
| Target | GABA-A receptor, NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a halogenated ether that acts as a general anesthetic by modulating multiple ion channels and neurotransmitter receptors in the brain. It enhances the activity of inhibitory GABA-A receptors while simultaneously blocking excitatory NMDA glutamate receptors, resulting in rapid loss of consciousness and anesthesia. The exact molecular mechanisms remain incompletely understood but involve disruption of neuronal signaling at multiple levels.
Approved indications
- Induction and maintenance of general anesthesia in adults and pediatric patients
Common side effects
- Emergence delirium
- Postoperative nausea and vomiting
- Airway irritation
- Hypotension
- Bradycardia
- Hepatotoxicity (rare)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)
- Deep Versus Moderate Neuromuscular Blocking (NA)
- Low-flow Versus Minimal-flow Sevoflurane Anesthesia During Robot-assisted Laparoscopic Radical Prostatectomy (NA)
- Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy (NA)
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- Perioperative Hypothermia and Sevoflurane Consumption in Elderly Patients
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |