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Sevoflurane / Remifentanil
Sevoflurane is a volatile anesthetic that depresses central nervous system activity, while remifentanil is an opioid agonist that provides analgesia and enhances anesthesia.
Sevoflurane is a volatile anesthetic that depresses central nervous system activity, while remifentanil is an opioid agonist that provides analgesia and enhances anesthesia. Used for General anesthesia for surgical procedures, Intraoperative analgesia and anesthesia maintenance.
At a glance
| Generic name | Sevoflurane / Remifentanil |
|---|---|
| Sponsor | Technical University of Munich |
| Drug class | General anesthetic (sevoflurane) + opioid analgesic (remifentanil) |
| Target | GABA receptors (sevoflurane); mu-opioid receptor (remifentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane acts as a general anesthetic by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling in the CNS, producing unconsciousness and amnesia. Remifentanil is a selective mu-opioid receptor agonist that provides rapid-onset analgesia and synergizes with sevoflurane to deepen anesthesia. Together, this combination is used for balanced general anesthesia during surgery.
Approved indications
- General anesthesia for surgical procedures
- Intraoperative analgesia and anesthesia maintenance
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Postoperative nausea and vomiting
- Emergence delirium
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery (NA)
- Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- The Effects of Three Different Anesthetic Methods on Postoperative Agitation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane / Remifentanil CI brief — competitive landscape report
- Sevoflurane / Remifentanil updates RSS · CI watch RSS
- Technical University of Munich portfolio CI