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Sevoflurane Inhalation Liquid
Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling. Used for Induction and maintenance of general anesthesia in adults and pediatric patients, Anesthesia for surgical procedures.
At a glance
| Generic name | Sevoflurane Inhalation Liquid |
|---|---|
| Sponsor | Damanhour Teaching Hospital |
| Drug class | Volatile general anesthetic |
| Target | GABA-A receptor, NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a halogenated ether that acts as a general anesthetic by modulating multiple ion channels and neurotransmitter receptors in the brain. It enhances the activity of inhibitory GABA-A receptors while simultaneously blocking excitatory NMDA glutamate receptors, resulting in rapid loss of consciousness and anesthesia. The exact molecular mechanisms remain incompletely understood but involve disruption of neuronal signaling pathways essential for consciousness.
Approved indications
- Induction and maintenance of general anesthesia in adults and pediatric patients
- Anesthesia for surgical procedures
Common side effects
- Postoperative nausea and vomiting
- Emergence delirium
- Airway irritation
- Hypotension
- Bradycardia
- Hepatotoxicity (rare)
Key clinical trials
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients (NA)
- Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery (NA)
- Minimal Flow Anesthesia and Infection Risk (NA)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Tubeless Anesthesia in Preventing Lung Complications in Patients Undergoing Surgery for Early-Stage Lung Cancer (NA)
- Postoperative Effects of Propofol Versus Sevoflurane Anesthesia (PHASE4)
- Enhanced Recovery After Urologic Surgery (NA)
- Individual Cerebral Hemodynamic Oxygenation Relationships (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane Inhalation Liquid CI brief — competitive landscape report
- Sevoflurane Inhalation Liquid updates RSS · CI watch RSS
- Damanhour Teaching Hospital portfolio CI