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Sevoflurane + Fentanyl
Sevoflurane is a volatile anesthetic that depresses central nervous system activity, while fentanyl is an opioid analgesic that binds to mu-opioid receptors to provide analgesia and sedation.
Sevoflurane is a volatile anesthetic that depresses central nervous system activity, while fentanyl is an opioid analgesic that binds to mu-opioid receptors to provide analgesia and sedation. Used for General anesthesia for surgical procedures, Balanced anesthesia with analgesia during surgery.
At a glance
| Generic name | Sevoflurane + Fentanyl |
|---|---|
| Sponsor | Azienda Ospedaliera San Gerardo di Monza |
| Drug class | General anesthetic + opioid analgesic combination |
| Target | GABA receptors (sevoflurane); mu-opioid receptors (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Sevoflurane acts as a general anesthetic by enhancing inhibitory GABAergic neurotransmission and inhibiting excitatory glutamatergic signaling in the central nervous system, producing unconsciousness and amnesia. Fentanyl potentiates this effect by activating mu-opioid receptors, providing analgesia and additional sedation. Together, this combination is used for balanced anesthesia during surgical procedures.
Approved indications
- General anesthesia for surgical procedures
- Balanced anesthesia with analgesia during surgery
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Postoperative cognitive dysfunction
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Comparison of Gastric Insufflation Volume Between LarySeal Pro and Ambu AuraGain Using Ultrasonography In Pediatric Patients Undergoing General Anesthesia With Controlled Ventilation. (NA)
- qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane + Fentanyl CI brief — competitive landscape report
- Sevoflurane + Fentanyl updates RSS · CI watch RSS
- Azienda Ospedaliera San Gerardo di Monza portfolio CI