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Sevoflurane and Remifentanil
Sevoflurane is a volatile anesthetic that depresses the central nervous system, while remifentanil is a potent synthetic opioid that provides analgesia and enhances anesthesia.
Sevoflurane is a volatile anesthetic that depresses the central nervous system, while remifentanil is a potent synthetic opioid that provides analgesia and enhances anesthesia. Used for General anesthesia for surgical procedures, Induction and maintenance of anesthesia in adult and pediatric patients.
At a glance
| Generic name | Sevoflurane and Remifentanil |
|---|---|
| Sponsor | University General Hospital of Patras |
| Drug class | General anesthetic (sevoflurane) and synthetic opioid analgesic (remifentanil) |
| Target | GABA receptors (sevoflurane); mu-opioid receptor (remifentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane acts as a general anesthetic by enhancing inhibitory GABAergic neurotransmission and inhibiting excitatory glutamatergic signaling in the central nervous system, producing unconsciousness and amnesia. Remifentanil is a mu-opioid receptor agonist that provides rapid-onset analgesia and sedation through activation of opioid receptors in the brain and spinal cord. Together, they are commonly used as a balanced anesthetic combination for induction and maintenance of general anesthesia during surgery.
Approved indications
- General anesthesia for surgical procedures
- Induction and maintenance of anesthesia in adult and pediatric patients
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Postoperative nausea and vomiting
- Emergence delirium
- Muscle rigidity
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery (NA)
- Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- The Effects of Three Different Anesthetic Methods on Postoperative Agitation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane and Remifentanil CI brief — competitive landscape report
- Sevoflurane and Remifentanil updates RSS · CI watch RSS
- University General Hospital of Patras portfolio CI