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Sequential therapy
Sequential therapy refers to a treatment approach that administers multiple therapeutic agents in a planned sequence rather than simultaneously, optimizing efficacy and tolerability.
At a glance
| Generic name | Sequential therapy |
|---|---|
| Also known as | Omeprazole-Amoxicillin-Clarithromycin-Metronidazole, Amoxicillin 1000 mg orally twice daily for 5 days, Omeprazole 20 mg orally twice daily for 5 days, Then, Clarithromycin 500 mg orally twice daily for 5 days |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
Sequential therapy is a treatment strategy rather than a single drug entity, involving the administration of different therapeutic agents one after another according to a defined protocol. This approach allows for dose optimization, assessment of response between phases, and potential reduction of cumulative toxicity compared to concurrent administration. The specific mechanism depends entirely on the individual drugs used in the sequence.
Approved indications
Common side effects
Key clinical trials
- Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma (PHASE1, PHASE2)
- Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda (PHASE2)
- A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma (NA)
- Dose Escalation Study Evaluating Safety of TheraSphere Prostate Cancer (PCa) Device (NA)
- Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies (PHASE1)
- "Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children." (NA)
- Reduced Elective Nodal and CTV Dose for HPV+ Oropharyngeal Squamous Cell Carcinoma (PHASE2)
- Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO]) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |