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Sensodyne Repair and Protect
Sensodyne Repair and Protect desensitizes exposed dentin tubules and builds a protective barrier to reduce tooth sensitivity pain.
Sensodyne Repair and Protect desensitizes exposed dentin tubules and builds a protective barrier to reduce tooth sensitivity pain. Used for Dentin hypersensitivity (tooth sensitivity pain relief), Enamel protection and remineralization.
At a glance
| Generic name | Sensodyne Repair and Protect |
|---|---|
| Also known as | Dentifrice with desensitizing agents, no other names |
| Sponsor | GlaxoSmithKline |
| Drug class | Desensitizing toothpaste |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Care |
| Phase | FDA-approved |
Mechanism of action
The toothpaste contains strontium acetate and sodium fluoride, which work together to occlude exposed dentin tubules (the microscopic channels in tooth structure that lead to the nerve) and remineralize tooth enamel. Strontium ions block the tubules from the inside, while fluoride strengthens enamel and reduces sensitivity transmission to the nerve.
Approved indications
- Dentin hypersensitivity (tooth sensitivity pain relief)
- Enamel protection and remineralization
Common side effects
- Mild gum irritation
- Temporary tooth discoloration
Key clinical trials
- A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching (PHASE4)
- A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome (NA)
- Evaluation of the Combined Effect of Bioactive Toothpastes, Desensitizing Agents and Er-YAG Laser on Dentin Hypersensitivity: an In-Vivo Study (NA)
- A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste for the Relief of Dentine Hypersensitivity in a Chinese Population (NA)
- Clinical Efficacy of Calcium and Sodium Phosphosilicate (Novamin) in the Treatment of MIH (Molar Incisor Hypolimineralization) in Pediatric Patients (NA)
- Comparative Clinical Evaluation of Three Different Agents in Reducing Dental Hypersensitivity in Periodontal Patients (PHASE4)
- Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic Rhinitis (NA)
- A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Dentifrice in the Relief of Dentinal Hypersensitivity in a Chinese Population (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sensodyne Repair and Protect CI brief — competitive landscape report
- Sensodyne Repair and Protect updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI