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Senna alone
Senna stimulates colonic muscle contractions and increases intestinal fluid secretion to promote bowel movements.
Senna stimulates colonic muscle contractions and increases intestinal fluid secretion to promote bowel movements. Used for Constipation, Bowel preparation before diagnostic procedures.
At a glance
| Generic name | Senna alone |
|---|---|
| Also known as | X-M solution (300 mg sennoside A+B calcium, Yenisehir Pharmaceuticals) |
| Sponsor | Camlıca Erdem Hospital |
| Drug class | Stimulant laxative |
| Target | Colonic smooth muscle and intestinal epithelium |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Senna contains anthraquinone glycosides (sennosides) that are metabolized by colonic bacteria into active aglycones. These compounds irritate the colonic mucosa and stimulate peristalsis while also increasing water and electrolyte secretion into the intestinal lumen, resulting in a laxative effect that typically occurs 6-12 hours after ingestion.
Approved indications
- Constipation
- Bowel preparation before diagnostic procedures
Common side effects
- Abdominal cramping
- Diarrhea
- Nausea
- Electrolyte imbalance (with chronic use)
- Melanosis coli (with prolonged use)
Key clinical trials
- Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma (PHASE2)
- ACL-R Opioid Sparing Study (PHASE3)
- Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery (PHASE3)
- A Clinical Study to Evaluate the Efficacy of Four Supplements on Improving Readiness for Intimacy (NA)
- Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids (PHASE4)
- Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery (PHASE3)
- Bowel Preparation in Elective Pediatric Colorectal Surgery (NA)
- Adding Stewed Apricot Juice to Senna Improves the Right-Side and Overall Colon Cleansing Quality for Colonoscopy Preparation (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Senna alone CI brief — competitive landscape report
- Senna alone updates RSS · CI watch RSS
- Camlıca Erdem Hospital portfolio CI