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Semaglutide Pen Injector
Semaglutide Pen Injector is a GLP-1 receptor agonist Small molecule drug developed by University of Pennsylvania. It is currently FDA-approved for Type 2 diabetes mellitus, Chronic weight management in adults with obesity or overweight with weight-related comorbidities. Also known as: Ozempic, Wegovy®, Wegovy, Placebo Semaglutide 1mg.
Semaglutide activates GLP-1 receptors to increase insulin secretion, slow gastric emptying, and reduce appetite, thereby lowering blood glucose and body weight.
Semaglutide activates GLP-1 receptors to increase insulin secretion, slow gastric emptying, and reduce appetite, thereby lowering blood glucose and body weight. Used for Type 2 diabetes mellitus, Chronic weight management in adults with obesity or overweight with weight-related comorbidities.
At a glance
| Generic name | Semaglutide Pen Injector |
|---|---|
| Also known as | Ozempic, Wegovy®, Wegovy, Placebo Semaglutide 1mg, Placebo Ozempic |
| Sponsor | University of Pennsylvania |
| Drug class | GLP-1 receptor agonist |
| Target | GLP-1R |
| Modality | Small molecule |
| Therapeutic area | Diabetes, Obesity |
| Phase | FDA-approved |
Mechanism of action
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the natural hormone GLP-1. It stimulates pancreatic beta cells to release insulin in response to elevated blood glucose, delays gastric emptying to slow nutrient absorption, and acts on the central nervous system to reduce hunger and food intake. These combined effects result in improved glycemic control and significant weight loss.
Approved indications
- Type 2 diabetes mellitus
- Chronic weight management in adults with obesity or overweight with weight-related comorbidities
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
- Hypoglycemia
Key clinical trials
- AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight (PHASE3)
- A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes (PHASE3)
- Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3) (PHASE2)
- Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (PHASE3)
- A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes (PHASE3)
- JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity (PHASE4)
- Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice
- The Effects of Semaglutide on Body Composition and Performance in Military Personnel (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Semaglutide Pen Injector CI brief — competitive landscape report
- Semaglutide Pen Injector updates RSS · CI watch RSS
- University of Pennsylvania portfolio CI
Frequently asked questions about Semaglutide Pen Injector
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Related
- Drug class: All GLP-1 receptor agonist drugs
- Target: All drugs targeting GLP-1R
- Manufacturer: University of Pennsylvania — full pipeline
- Therapeutic area: All drugs in Diabetes, Obesity
- Indication: Drugs for Type 2 diabetes mellitus
- Indication: Drugs for Chronic weight management in adults with obesity or overweight with weight-related comorbidities
- Also known as: Ozempic, Wegovy®, Wegovy, Placebo Semaglutide 1mg, Placebo Ozempic
- Compare: Semaglutide Pen Injector vs similar drugs
- Pricing: Semaglutide Pen Injector cost, discount & access