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Selenium Supplement
Selenium acts as a cofactor for selenoproteins, which function as antioxidant enzymes that protect cells from oxidative damage.
Selenium acts as a cofactor for selenoproteins, which function as antioxidant enzymes that protect cells from oxidative damage. Used for Selenium deficiency prevention and treatment, Antioxidant support in various disease states.
At a glance
| Generic name | Selenium Supplement |
|---|---|
| Also known as | Zelnite |
| Sponsor | Chang Gung Memorial Hospital |
| Drug class | Micronutrient/Dietary supplement |
| Target | Selenoprotein synthesis (multiple selenoproteins including GPx, TrxR) |
| Modality | Small molecule |
| Therapeutic area | Nutritional supplementation; Antioxidant support |
| Phase | FDA-approved |
Mechanism of action
Selenium is incorporated into selenoproteins such as glutathione peroxidase and thioredoxin reductase, which catalyze the reduction of hydrogen peroxide and other reactive oxygen species. This antioxidant activity helps maintain cellular redox balance and supports immune function, thyroid hormone metabolism, and protection against oxidative stress-related diseases.
Approved indications
- Selenium deficiency prevention and treatment
- Antioxidant support in various disease states
Common side effects
- Selenosis (excessive selenium toxicity)
- Gastrointestinal upset
- Hair and nail brittleness
Key clinical trials
- Selenium Supplementation in Moderate-Severely Active Ulcerative Colitis Patients Treated With Advanced Therapies (PHASE2)
- A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV. (NA)
- Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial (NA)
- Chemo Brain Prehab Project (NA)
- Alii Supplement Study (PHASE2)
- Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF (NA)
- A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure (PHASE3)
- Micronutrient Dose Response Study in Bangladesh (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |