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Second-line Antipsychotics
Second-line antipsychotics work by blocking dopamine receptors in the brain, reducing psychotic symptoms.
Second-line antipsychotics work by blocking dopamine receptors in the brain, reducing psychotic symptoms. Used for Treatment of schizophrenia, Treatment of bipolar disorder.
At a glance
| Generic name | Second-line Antipsychotics |
|---|---|
| Sponsor | Dr. Inge Winter |
| Drug class | Second-line antipsychotic |
| Target | D2 receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | Phase 3 |
Mechanism of action
They achieve this by selectively binding to D2 receptors, which are involved in the regulation of movement and emotion. This blockade helps to alleviate symptoms of schizophrenia and other psychotic disorders.
Approved indications
- Treatment of schizophrenia
- Treatment of bipolar disorder
Common side effects
- Weight gain
- Dyslipidemia
- Metabolic syndrome
Key clinical trials
- Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure (PHASE3)
- The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (PHASE4)
- A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients (NA)
- Antipsychotics and Blood Vessel Function
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |