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Sealant, Fissure
A dental sealant that physically blocks fissures and pits on tooth surfaces to prevent bacterial colonization and dental caries.
A dental sealant that physically blocks fissures and pits on tooth surfaces to prevent bacterial colonization and dental caries. Used for Prevention of dental caries (cavities) in fissures and pits of permanent molars and premolars.
At a glance
| Generic name | Sealant, Fissure |
|---|---|
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak |
| Drug class | Dental preventive sealant |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Preventive Oral Health |
| Phase | Phase 3 |
Mechanism of action
Fissure sealants are resin-based or glass ionomer materials that are applied to the occlusal (chewing) surfaces of teeth, particularly molars and premolars. They flow into and mechanically seal the natural grooves and fissures where food debris and bacteria accumulate, creating a physical barrier that prevents cavity formation in these high-risk areas.
Approved indications
- Prevention of dental caries (cavities) in fissures and pits of permanent molars and premolars
Common side effects
- Sealant retention loss
- Allergic reaction to resin components
- Microleakage at sealant margins
Key clinical trials
- Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC (NA)
- Building Adaptive School-based Interventions for Caries (PHASE3)
- A Comparative Evaluation of the Role of Self-Adhesive Flowable Composite in Enhancing Sealant Retention Versus Conventional Pits and Fissure Sealant With and Without Fissurotomy in Permanent Molars (NA)
- Glass Ionomer-Based Fissure Sealants in Children (NA)
- Retention Rate And Caries Prevention Of Giomer Based Sealant With And Without Pre-Treatment With Bioactive Glass Air Abrasion In Young Adults (NA)
- Retention of Pits and Fissure Sealants on Non Carious vs Initial Carious Enamel Lesions in Posterior Teeth
- Evaluation of the Clinical Success of Hydrophilic Fissure Sealants (NA)
- Sealant Application by Interns After Tele-demonstration (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sealant, Fissure CI brief — competitive landscape report
- Sealant, Fissure updates RSS · CI watch RSS
- Postgraduate Institute of Dental Sciences Rohtak portfolio CI