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Saline (Syringe irrigation)
Saline irrigation mechanically cleanses and flushes surgical or wound sites by delivering sterile sodium chloride solution to remove debris, bacteria, and foreign material.
Saline irrigation mechanically cleanses and flushes surgical or wound sites by delivering sterile sodium chloride solution to remove debris, bacteria, and foreign material. Used for Surgical site irrigation during procedures, Wound cleansing and management, Post-operative irrigation.
At a glance
| Generic name | Saline (Syringe irrigation) |
|---|---|
| Sponsor | Khon Kaen University |
| Drug class | Irrigating solution / Wound care agent |
| Modality | Small molecule |
| Therapeutic area | Surgery / Wound Care |
| Phase | Phase 3 |
Mechanism of action
Saline solution (0.9% sodium chloride) is isotonic with human plasma and serves as a gentle, non-toxic irrigant for wound and surgical site management. It works through mechanical flushing action to remove contaminants, exudate, and necrotic tissue without damaging healthy tissue or disrupting the wound environment. The solution maintains physiologic osmolarity and electrolyte balance, making it suitable for frequent irrigation during procedures and post-operative care.
Approved indications
- Surgical site irrigation during procedures
- Wound cleansing and management
- Post-operative irrigation
Common side effects
- Minimal systemic toxicity (non-absorbed topical use)
- Local irritation if contaminated
Key clinical trials
- Evaluating Postoperative Pain and Antibacterial Effect of Ultrasonic and 980 nm Diode Laser Combination (NA)
- Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic (NA)
- Microbiota Transfer for Chronic Rhinosinusitis (NA)
- Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty (PHASE1)
- Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative (NA)
- Trial Evaluating the Efficacy of Local Budesonide Therapy in the Management of Hyposmia in COVID-19 Patients Without Signs of Severity (PHASE3)
- Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery (NA)
- Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |