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Saline Solution (NaCl 0,9%)
Saline solution (0.9% NaCl) restores fluid and electrolyte balance by providing isotonic sodium chloride that matches blood osmolarity.
Saline solution (0.9% NaCl) restores fluid and electrolyte balance by providing isotonic sodium chloride that matches blood osmolarity. Used for Fluid and electrolyte replacement in dehydration, Maintenance of intravascular volume during surgery or critical illness, Vehicle for intravenous medication administration.
At a glance
| Generic name | Saline Solution (NaCl 0,9%) |
|---|---|
| Also known as | Saline solution |
| Sponsor | Université du Québec à Trois-Rivières |
| Drug class | Crystalloid fluid / Electrolyte replacement |
| Modality | Small molecule |
| Therapeutic area | Fluid and Electrolyte Management |
| Phase | FDA-approved |
Mechanism of action
Normal saline is an isotonic crystalloid solution containing 0.9% sodium chloride (154 mEq/L each of Na+ and Cl−), which matches the osmolarity of blood plasma (~308 mOsm/L). It is used for fluid replacement and electrolyte supplementation without causing cellular water shifts. The solution distributes primarily to the extracellular compartment and is used for hydration, maintenance of electrolyte balance, and as a vehicle for intravenous medications.
Approved indications
- Fluid and electrolyte replacement in dehydration
- Maintenance of intravascular volume during surgery or critical illness
- Vehicle for intravenous medication administration
- Treatment of hyponatremia (in specific clinical contexts)
Common side effects
- Hyperchloremic acidosis (with large-volume infusion)
- Fluid overload / pulmonary edema (in susceptible patients)
- Hypernatremia (rare, with excessive administration)
- Phlebitis at infusion site
Key clinical trials
- Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts (NA)
- HPV Vaccine Reduced Dose (PHASE4)
- Mix and Match of the COVID-19 Vaccine for Safety and Immunogenicity (PHASE2)
- Effect of Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Pain After Colorectal Surgery (NA)
- Precise Transplantation of hAESCs Into the Ventricle for Parkinson's Disease. (EARLY_PHASE1)
- Improving Neuroprotective Strategy for Ischemic Stroke With Sufficient Recanalization After Thrombectomy by Edaravone Dexborneol (PHASE2)
- Sedation for Non-invasive Ventilation in Blunt Chest Trauma (NA)
- Esketamine vs. Ketorolac for Prevention of Postoperative Pain and Cognitive Dysfunction After Total Knee Arthroplasty (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |