Last reviewed · How we verify
Saline solution isotonic 0.9% NaCl
Isotonic saline solution restores fluid and electrolyte balance by providing sodium chloride and water in physiologically equivalent concentrations to blood plasma.
Isotonic saline solution restores fluid and electrolyte balance by providing sodium chloride and water in physiologically equivalent concentrations to blood plasma. Used for Fluid and electrolyte replacement in dehydration, Maintenance of vascular access and drug delivery vehicle, Perioperative fluid management.
At a glance
| Generic name | Saline solution isotonic 0.9% NaCl |
|---|---|
| Also known as | physiological Saline solution 0.9% NaCl |
| Sponsor | Krankenhaus Barmherzige Schwestern Linz |
| Drug class | Crystalloid fluid / Electrolyte replacement solution |
| Modality | Small molecule |
| Therapeutic area | General supportive care / Fluid and electrolyte management |
| Phase | FDA-approved |
Mechanism of action
0.9% NaCl solution is osmotically balanced with human blood, meaning it has the same osmotic pressure as plasma. When administered intravenously, it replaces lost fluids and electrolytes without causing water to shift between cellular and extracellular compartments. It is used for hydration, electrolyte replacement, and as a vehicle for drug delivery.
Approved indications
- Fluid and electrolyte replacement in dehydration
- Maintenance of vascular access and drug delivery vehicle
- Perioperative fluid management
- Treatment of hypovolemia and shock
Common side effects
- Hyperchloremic acidosis
- Fluid overload / Pulmonary edema
- Hypernatremia
- Phlebitis at infusion site
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction (PHASE2)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
- Normal Saline Infusion After Intravenous Thrombolysis in Stroke (PHASE3)
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome (PHASE4)
- The Development of New Functions of Esculin and Digitalis Glycosides Eye Drops: A Study on the Treatment of Presbyopia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: