Last reviewed 2026-04-23 · How we verify

Saline Solution for Block

Saline solution provides a sterile, isotonic fluid medium for regional anesthetic block procedures.

Saline solution provides a sterile, isotonic fluid medium for regional anesthetic block procedures. Used for Regional anesthetic blocks (nerve blocks, epidural blocks, spinal blocks).

At a glance

Mechanism of action

Saline solution (0.9% sodium chloride) serves as a vehicle for delivering local anesthetics or other agents during nerve blocks and regional anesthesia. It maintains osmotic balance and tissue compatibility, ensuring safe infiltration and distribution of blocking agents to target nerve tissues without causing cellular damage or adverse osmotic effects.

Approved indications

• Regional anesthetic blocks (nerve blocks, epidural blocks, spinal blocks)

Common side effects

• Local tissue irritation
• Infection at injection site
• Nerve injury

Key clinical trials

• Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function (NA)
• Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
• Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
• A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade (PHASE2)
• mTLIP vs QIPB for Postoperative Analgesia in Lumbar Microdiscectomy Surgery (NA)
• Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
• Comparison of the Effectiveness of Exercise, Dry Needling and Interfascial Block Treatments in the Treatment of Myofascial Pain Syndrome (NA)
• Does the Common Practice of Adding Diluted Epinephrine in Tranverse Abdominal Plan Block to Ropivacaine Significantly Decrease the Peak Systemic Resorption of Ropivacaine? (NA)

Primary sources

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