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Saline solution ("B")
Saline solution provides electrolyte and fluid replacement by delivering sodium chloride and water to restore osmotic balance and hydration status.
Saline solution provides electrolyte and fluid replacement by delivering sodium chloride and water to restore osmotic balance and hydration status. Used for Fluid and electrolyte replacement in dehydration, Perioperative fluid management, Vehicle for intravenous medication delivery.
At a glance
| Generic name | Saline solution ("B") |
|---|---|
| Sponsor | Hospital Universitari de Bellvitge |
| Drug class | Electrolyte solution / Fluid replacement |
| Modality | Small molecule |
| Therapeutic area | General supportive care / Fluid and electrolyte management |
| Phase | FDA-approved |
Mechanism of action
Saline solution is an isotonic or hypertonic aqueous preparation of sodium chloride that restores intravascular and extracellular fluid volume. It serves as a physiological replacement for lost fluids and electrolytes, maintaining proper osmotic pressure and cellular function. Saline has no active pharmacological mechanism but acts as a vehicle for fluid resuscitation and medication delivery.
Approved indications
- Fluid and electrolyte replacement in dehydration
- Perioperative fluid management
- Vehicle for intravenous medication delivery
- Maintenance of vascular access patency
Common side effects
- Hyperchloremic acidosis (with prolonged high-volume use)
- Hypernatremia (with excessive administration)
- Fluid overload / pulmonary edema (in susceptible patients)
- Phlebitis (at infusion site)
Key clinical trials
- Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
- Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis (PHASE2)
- A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults (PHASE1, PHASE2)
- Auto Transplant High Dose Melphalan vs High Dose Melphalan+Bortezomib in Pts With Multiple Myeloma Age 65 Years or Older (PHASE2)
- Volume Reduction for Open Fracture Irrigation (PHASE4)
- Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults (PHASE1)
- Evaluating rhPDGF-BB-Enhanced Wound Matrix for Head and Neck Reconstruction (PHASE2)
- Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Saline solution ("B") CI brief — competitive landscape report
- Saline solution ("B") updates RSS · CI watch RSS
- Hospital Universitari de Bellvitge portfolio CI