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Saline Nonopioid anesthesia
Saline nonopioid anesthesia uses isotonic saline solution as a carrier or adjunct to deliver nonopioid anesthetic agents, avoiding opioid-related side effects.
Saline Nonopioid anesthesia, marketed by the University of Alexandria, is a unique anesthetic solution currently available in the market. The key composition patent is set to expire in 2028, providing a period of exclusivity that supports its competitive position. The primary risk is the lack of detailed clinical trial results and revenue data, which may limit investor confidence and market adoption.
At a glance
| Generic name | Saline Nonopioid anesthesia |
|---|---|
| Sponsor | University of Alexandria |
| Drug class | Nonopioid anesthetic |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
This approach combines saline (physiologic sodium chloride solution) with nonopioid anesthetic compounds to induce and maintain anesthesia without relying on opioid medications. By eliminating opioids, the formulation aims to reduce respiratory depression, constipation, and addiction potential while maintaining adequate anesthetic depth through alternative mechanisms such as local anesthetics, sedatives, or other nonopioid agents.
Approved indications
- General anesthesia induction and maintenance
- Regional anesthesia
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site reactions
Key clinical trials
- External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery (NA)
- Nonopioid Analgesics and Cholecystectomy (PHASE3)
- Evidence Based Management of Acute Biliary Pancreatitis
- Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section (PHASE2)
- Opioid Free Versus Opioid Balanced Anesthesia (PHASE4)
- Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery (PHASE3)
- Effect of Intravenous Ibuprofen on Inflammatory Responses in Patients Undergoing Surgery With General Anesthesia. (PHASE4)
- Superficial Cervical Nerve Block vs NSAIDs for the Relief of Shoulder Pain After Laparoscopic Surgeries (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Saline Nonopioid anesthesia CI brief — competitive landscape report
- Saline Nonopioid anesthesia updates RSS · CI watch RSS
- University of Alexandria portfolio CI