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Saline (NaCl)
Saline (NaCl) is a Electrolyte solution / Crystalloid fluid Small molecule drug developed by VZW Cardiovascular Research Center Aalst. It is currently FDA-approved for Fluid resuscitation and electrolyte replacement, Vehicle for intravenous drug administration, Maintenance of intravascular volume in cardiovascular procedures.
Saline (NaCl) restores fluid and electrolyte balance by providing sodium and chloride ions in an isotonic solution that matches blood osmolarity.
Saline (NaCl) is a solution used in medical research to study various conditions, including Acute Pain, Ventilator Associated Pneumonia, and Acute Ischemic Stroke. It is also used as a control intervention in clinical trials, such as the study of dexamethasone's effects on post-operative pain control after total knee replacement.
At a glance
| Generic name | Saline (NaCl) |
|---|---|
| Sponsor | VZW Cardiovascular Research Center Aalst |
| Drug class | Electrolyte solution / Crystalloid fluid |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / General supportive care |
| Phase | FDA-approved |
Mechanism of action
Saline is a simple electrolyte solution containing sodium chloride dissolved in water. When administered intravenously, it replaces lost fluids and electrolytes, maintaining proper osmotic balance and supporting cardiovascular function. It is used as a basic resuscitation fluid and vehicle for drug delivery in clinical settings.
Approved indications
- Fluid resuscitation and electrolyte replacement
- Vehicle for intravenous drug administration
- Maintenance of intravascular volume in cardiovascular procedures
Common side effects
- Hyperchloremic acidosis
- Fluid overload / pulmonary edema
- Hypernatremia
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomized Trial) (NA)
- Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction (PHASE2)
- Effects of Bronchial Segmental Endotoxin Instillation in Humans (PHASE2)
- Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- Inflammatory Challenge in Human Aggression. (PHASE2)
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Saline (NaCl) CI brief — competitive landscape report
- Saline (NaCl) updates RSS · CI watch RSS
- VZW Cardiovascular Research Center Aalst portfolio CI
Frequently asked questions about Saline (NaCl)
What is Saline (NaCl)?
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Related
- Drug class: All Electrolyte solution / Crystalloid fluid drugs
- Manufacturer: VZW Cardiovascular Research Center Aalst — full pipeline
- Therapeutic area: All drugs in Cardiovascular / General supportive care
- Indication: Drugs for Fluid resuscitation and electrolyte replacement
- Indication: Drugs for Vehicle for intravenous drug administration
- Indication: Drugs for Maintenance of intravascular volume in cardiovascular procedures
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing