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saline infiltration
Saline infiltration is a procedure that delivers sterile saline solution into tissue to create hydrodissection and facilitate surgical separation of tissue planes.
Saline infiltration is a procedure that delivers sterile saline solution into tissue to create hydrodissection and facilitate surgical separation of tissue planes. Used for Surgical hydrodissection and tissue plane separation during dermatologic procedures, Ophthalmic surgical procedures requiring tissue separation.
At a glance
| Generic name | saline infiltration |
|---|---|
| Sponsor | Louisiana State University Health Sciences Center in New Orleans |
| Modality | Small molecule |
| Therapeutic area | Surgery/Procedural |
| Phase | FDA-approved |
Mechanism of action
Saline infiltration involves injecting sterile normal saline (0.9% sodium chloride) into subcutaneous or submucosal tissue layers to create a fluid cushion that separates tissue planes and reduces bleeding during surgical procedures. This hydrodissection technique allows surgeons to work more safely and precisely by creating a clear plane of separation between anatomical structures. It is commonly used in dermatologic, ophthalmic, and general surgical procedures.
Approved indications
- Surgical hydrodissection and tissue plane separation during dermatologic procedures
- Ophthalmic surgical procedures requiring tissue separation
Common side effects
- Tissue edema
- Temporary swelling at injection site
- Bruising
Key clinical trials
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension (PHASE4)
- CPL-01 in the Management of Postoperative Pain After Bunionectomy (PHASE3)
- Herniorrhaphy for Postoperative Pain (PHASE3)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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