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Salbutamol pMDI
Salbutamol pMDI is a Short-acting beta-2 adrenergic agonist (SABA) Small molecule drug developed by AstraZeneca. It is currently in Phase 3 development for Acute relief of bronchospasm in asthma, Acute relief of bronchospasm in chronic obstructive pulmonary disease (COPD), Prevention of exercise-induced bronchospasm. Also known as: Saltanol.
Salbutamol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing rapid bronchodilation and relief of airway obstruction.
Salbutamol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing rapid bronchodilation and relief of airway obstruction. Used for Acute relief of bronchospasm in asthma, Acute relief of bronchospasm in chronic obstructive pulmonary disease (COPD), Prevention of exercise-induced bronchospasm.
At a glance
| Generic name | Salbutamol pMDI |
|---|---|
| Also known as | Saltanol |
| Sponsor | AstraZeneca |
| Drug class | Short-acting beta-2 adrenergic agonist (SABA) |
| Target | Beta-2 adrenergic receptor (ADRB2) |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | Phase 3 |
Mechanism of action
Salbutamol activates beta-2 adrenergic receptors on bronchial smooth muscle cells, triggering a cascade that increases intracellular cAMP levels. This leads to smooth muscle relaxation and airway dilation, providing rapid symptomatic relief of bronchoconstriction. It is a short-acting beta-2 agonist (SABA) used primarily for acute relief of asthma and COPD symptoms.
Approved indications
- Acute relief of bronchospasm in asthma
- Acute relief of bronchospasm in chronic obstructive pulmonary disease (COPD)
- Prevention of exercise-induced bronchospasm
Common side effects
- Tremor
- Headache
- Nervousness or anxiety
- Palpitations
- Muscle cramps
- Tachycardia
Key clinical trials
- Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma. (PHASE3)
- Comparing the Efficacy of Two Valved Holding Chambers in Acute Wheezing (NA)
- Anti-Inflammatory Reliever South Africa (PHASE3)
- Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care (PHASE4)
- Assessment of Emergency Spacers Versus Traditional Spacers for Delivery of Aerosolized Drugs (PHASE4)
- CIVETTA: Correlating Inflammatory Values of FEno, SympToms, SpuTum and Lung Function in Asthma (PHASE2)
- Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging (PHASE1)
- Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Salbutamol pMDI CI brief — competitive landscape report
- Salbutamol pMDI updates RSS · CI watch RSS
- AstraZeneca portfolio CI
Frequently asked questions about Salbutamol pMDI
What is Salbutamol pMDI?
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Related
- Drug class: All Short-acting beta-2 adrenergic agonist (SABA) drugs
- Target: All drugs targeting Beta-2 adrenergic receptor (ADRB2)
- Manufacturer: AstraZeneca — full pipeline
- Therapeutic area: All drugs in Respiratory
- Indication: Drugs for Acute relief of bronchospasm in asthma
- Indication: Drugs for Acute relief of bronchospasm in chronic obstructive pulmonary disease (COPD)
- Indication: Drugs for Prevention of exercise-induced bronchospasm
- Also known as: Saltanol
- Compare: Salbutamol pMDI vs similar drugs
- Pricing: Salbutamol pMDI cost, discount & access