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Saffron tablet
Saffron (Crocus sativus) exerts therapeutic effects primarily through its active constituents crocin and safranal, which possess antioxidant, anti-inflammatory, and neuroprotective properties.
Saffron (Crocus sativus) exerts therapeutic effects primarily through its active constituents crocin and safranal, which possess antioxidant, anti-inflammatory, and neuroprotective properties. Used for Depression (mild to moderate), Cognitive dysfunction, Age-related macular degeneration.
At a glance
| Generic name | Saffron tablet |
|---|---|
| Also known as | crocin, safranal |
| Sponsor | Birjand University of Medical Sciences |
| Drug class | Herbal/botanical extract |
| Modality | Small molecule |
| Therapeutic area | Psychiatry/Neurology |
| Phase | FDA-approved |
Mechanism of action
The active compounds in saffron, particularly crocin and safranal, work by scavenging free radicals and reducing oxidative stress, while also modulating inflammatory pathways and potentially affecting monoamine neurotransmitter systems. These mechanisms contribute to its reported benefits in mood disorders, cognitive function, and various inflammatory conditions. The exact molecular targets remain incompletely characterized, but evidence suggests involvement of multiple pathways rather than a single receptor or enzyme.
Approved indications
- Depression (mild to moderate)
- Cognitive dysfunction
- Age-related macular degeneration
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
- Dry mouth
Key clinical trials
- Efficacy Study in Phytotherapy of an Association of Plants in the Improvement of Psychological Well-being (NA)
- Effects of AffronEye®/ Crocuvis+® on Dry Eye Syndrome (NA)
- Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment (PHASE3)
- Follow up Study of Crocin on Cardiac Function Protection in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy Based on Color Doppler Ultrasound Combined With Myocardial Zymogram
- Effects of CROCUVIS+® on Computer Vision Syndrome, Sleep and Mood Disorders (NA)
- Protection of Cardiovascular Function With Crocin in BrEast Cancer Patients Undergoing Radiotherapy and Chemotherapy (NA)
- Saffron and Ulcerative Colitis (PHASE2)
- Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Saffron tablet CI brief — competitive landscape report
- Saffron tablet updates RSS · CI watch RSS
- Birjand University of Medical Sciences portfolio CI