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Sabin IPV
Sabin IPV is an inactivated polio vaccine that stimulates the immune system to produce antibodies against all three poliovirus serotypes, preventing poliomyelitis infection.
Sabin IPV is an inactivated polio vaccine that stimulates the immune system to produce antibodies against all three poliovirus serotypes, preventing poliomyelitis infection. Used for Prevention of poliomyelitis caused by poliovirus serotypes 1, 2, and 3.
At a glance
| Generic name | Sabin IPV |
|---|---|
| Also known as | Sabin strain Inactivated Poliovirus Vaccine |
| Sponsor | Centers for Disease Control and Prevention, China |
| Drug class | inactivated viral vaccine |
| Target | poliovirus serotypes 1, 2, and 3 |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Sabin IPV contains chemically inactivated (killed) poliovirus particles of serotypes 1, 2, and 3. When administered, these antigens trigger both humoral (antibody) and cellular immune responses without causing disease. The resulting antibodies neutralize wild-type poliovirus and prevent viral replication in the gastrointestinal and nervous systems, thereby preventing paralytic poliomyelitis.
Approved indications
- Prevention of poliomyelitis caused by poliovirus serotypes 1, 2, and 3
Common side effects
- Injection site pain, redness, or swelling
- Fever
- Irritability or fussiness
Key clinical trials
- Phase IV Clinical Study of Sequential Vaccination of Sabin Strain and Wild Strain Inactivated Poliovirus Vaccine (PHASE4)
- Phase IV Clinical Study of sIPV Administration in Adolescent and Adult Populations (PHASE4)
- the Five-year Antibody Persistence After Immunization With IPV, MMR and HepA-L Vaccines
- Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh (PHASE2)
- Phase III Clinical Trial of Sabin Strain Inactivated Poliovirus Vaccine (Vero Cell) (PHASE3)
- A Multi-center, Open-labelled, Randomized, Controlled, Extended Phase Ⅲ Clinical Trial of sIPV Vaccine (PHASE3)
- A Study on the Immune Response and Safety of Inactivated Poliovirus Vaccine (IPV) When Co-administered With Human Rotavirus (HRV) Porcine Circovirus (PCV)-Free Vaccine in Healthy Chinese Infants (PHASE3)
- Study of Concomitant Administration of the sIPV and DTaP or MMR (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sabin IPV CI brief — competitive landscape report
- Sabin IPV updates RSS · CI watch RSS
- Centers for Disease Control and Prevention, China portfolio CI