Last reviewed · How we verify
S-adenosylmethionine
S-adenosylmethionine acts as a methyl donor in various enzymatic reactions.
S-adenosylmethionine acts as a methyl donor in various enzymatic reactions. Used for Depressive disorder, Chronic liver disease.
At a glance
| Generic name | S-adenosylmethionine |
|---|---|
| Sponsor | US Department of Veterans Affairs |
| Drug class | Methionine derivative |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | Phase 3 |
Mechanism of action
S-adenosylmethionine is involved in the methylation of DNA, RNA, and proteins, which plays a crucial role in various cellular processes. This process is essential for the regulation of gene expression and the maintenance of cellular homeostasis.
Approved indications
- Depressive disorder
- Chronic liver disease
Common side effects
- Nausea
- Headache
- Diarrhea
Key clinical trials
- Single-Center Phase II Double-Blind Trial of SAMe to Prevent Liver Cancer in MASLD-Related Cirrhosis (PHASE2)
- Ademetionine in Obstructive Hypertrophic Cardiomyopathy (PHASE2)
- SAMe in Prevention of Oxaliplatin-associated Liver Injury (PHASE2)
- Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia (NA)
- Development of a Diagnostic Prediction Score for Tuberculosis in Hospitalized Children With Severe Acute Malnutrition (TB-Speed SAM) (NA)
- SAMe Trial for Patients With Alcoholic Cirrhosis (PHASE2)
- From Yearly Checks to Daily Progress: Evaluating Goal Attainment Scaling (GAS) in Systematic Work Environment Management (SAM) Within the Municipal Sector (NA)
- Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |