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RVT-101
RVT-101 is a small molecule that targets the tau protein to treat neurodegenerative diseases.
RVT-101 is a small molecule that targets the tau protein to treat neurodegenerative diseases. Used for Alzheimer's disease.
At a glance
| Generic name | RVT-101 |
|---|---|
| Sponsor | Axovant Sciences Ltd. |
| Drug class | tau protein inhibitor |
| Target | tau protein |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
RVT-101 works by binding to the tau protein, which is implicated in the progression of neurodegenerative diseases such as Alzheimer's disease. By inhibiting tau aggregation, RVT-101 aims to slow down disease progression and improve symptoms.
Approved indications
- Alzheimer's disease
Common side effects
- Headache
- Dizziness
- Nausea
Key clinical trials
- Study Evaluating Intepirdine (RVT-101) on Gait and Balance in Subjects With Dementia (PHASE2)
- 12-Month Open-Label Extension Study of Intepirdine (RVT-101) in Subjects With Alzheimer's Disease: MINDSET Extension (PHASE3)
- Study Evaluating Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: The HEADWAY-DLB Study (PHASE2)
- Study Evaluating Intepirdine (RVT-101) in Subjects With Mild to Moderate Alzheimer's Disease on Donepezil: MINDSET Study (PHASE3)
- Study of SB-742457 or Donepezil Versus Placebo in Subjects With Mild-to-moderate Alzheimer's Disease (PHASE2)
- Long-Term Extension Study of Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: HEADWAY-DLB Extension (PHASE2, PHASE3)
- A Study of SB-742457, Added to Donepezil for the Treatment of Mild-to-moderate Alzheimer's Disease (PHASE2)
- A Dose Ranging Study To Investigate The Efficacy And Safety Of SB-742457 In Alzheimer's Disease (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- RVT-101 CI brief — competitive landscape report
- RVT-101 updates RSS · CI watch RSS
- Axovant Sciences Ltd. portfolio CI