Last reviewed · How we verify
RSVpreF (rsvpref)
RSVpreF, developed by Pfizer Inc., is a marketed drug used to prevent RSV lower respiratory tract disease in high-risk neonates, infants, and children. It is a monoclonal antibody that targets the RSV virus. The drug has shown significant clinical differentiation in its ability to prevent severe RSV disease. Its commercial significance is evident in its high revenue of $63.6 billion. With 164 publications and 26 trials, RSVpreF has a strong clinical foundation. The drug's mechanism of action involves binding to the RSV F protein, preventing the virus from entering host cells. As a marketed product, RSVpreF has established itself as a key player in the prevention of RSV disease.
At a glance
| Generic name | rsvpref |
|---|---|
| Sponsor | Pfizer |
| Drug class | Monoclonal antibody |
| Target | RSV F protein |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Approved indications
- Prevention of RSV lower respiratory tract disease in neonates at high risk of RSV disease
- Prevention of RSV lower respiratory tract disease in infants and children at high risk of RSV disease
Common side effects
Drug interactions
- CYP3A4 inhibitors
- CYP3A4 inducers
- Live attenuated influenza vaccine
- Live attenuated MMR vaccine
- Live attenuated varicella vaccine
- Live attenuated zoster vaccine
- Live or inactivated vaccines
- Pneumococcal conjugate vaccine
- Pneumococcal polysaccharide vaccine
- Rabies vaccine
- Typhoid vaccine
Key clinical trials
- The Immunology and Safety of Maternal RSV Vaccination (ABRYSVO), Infant Nirsevimab (BEYFORTUS) Immunization, or Both Products (PHASE4)
- A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose (PHASE3)
- Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy (PHASE4)
- TARSILA Real-World Evidence Study
- A Study to Assess the Safety, Tolerability, and Immunogenicity of RSVpreF in Older Adults in Korea (PHASE3)
- SPECIAL INVESTIGATION FOR ABRYSVO IN INDIVIDUALS AGED 60 YEARS OR OLDER
- Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults. (PHASE3)
- RSV Vaccine Response in Stem Cell and CAR-T Therapy Recipients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |