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rosiglitazone maleate/metformin hydrochloride
rosiglitazone maleate/metformin hydrochloride is a Thiazolidinedione/Biguanide combination Small molecule drug developed by GlaxoSmithKline. It is currently FDA-approved for Type 2 diabetes mellitus.
This combination drug improves blood sugar control by increasing insulin sensitivity through a thiazolidinedione and reducing hepatic glucose production through a biguanide.
This combination drug improves blood sugar control by increasing insulin sensitivity through a thiazolidinedione and reducing hepatic glucose production through a biguanide. Used for Type 2 diabetes mellitus.
At a glance
| Generic name | rosiglitazone maleate/metformin hydrochloride |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Thiazolidinedione/Biguanide combination |
| Target | PPAR-γ (rosiglitazone); Complex I of mitochondrial respiratory chain (metformin) |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | FDA-approved |
Mechanism of action
Rosiglitazone is a thiazolidinedione that activates peroxisome proliferator-activated receptor gamma (PPAR-γ), enhancing insulin sensitivity in muscle and adipose tissue. Metformin is a biguanide that decreases hepatic glucose production and improves peripheral glucose uptake. Together, they provide complementary mechanisms to reduce hyperglycemia in type 2 diabetes.
Approved indications
- Type 2 diabetes mellitus
Common side effects
- Weight gain
- Fluid retention/edema
- Hypoglycemia
- Gastrointestinal disturbances (nausea, diarrhea)
- Headache
- Upper respiratory tract infection
Key clinical trials
- Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
- Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies (PHASE2)
- Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh (PHASE4)
- Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) (PHASE3)
- Effect of Metformin and Rosiglitazone Over no Diabetic With Metabolic Syndrome Patients. (PHASE2, PHASE3)
- Predictive Markers of Glitazone Efficacy in Diabetic Patients - Pilot Study
- Effect of Inhaled Pre-prandial Human Insulin on Blood Glucose Control in Type 2 Diabetes (PHASE3)
- Effects of Fatty Acid Delivery on Heart Metabolism and Function in Type 2 Diabetes (T2DM (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- rosiglitazone maleate/metformin hydrochloride CI brief — competitive landscape report
- rosiglitazone maleate/metformin hydrochloride updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI
Frequently asked questions about rosiglitazone maleate/metformin hydrochloride
What is rosiglitazone maleate/metformin hydrochloride?
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Who makes rosiglitazone maleate/metformin hydrochloride?
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Related
- Drug class: All Thiazolidinedione/Biguanide combination drugs
- Target: All drugs targeting PPAR-γ (rosiglitazone); Complex I of mitochondrial respiratory chain (metformin)
- Manufacturer: GlaxoSmithKline — full pipeline
- Therapeutic area: All drugs in Diabetes
- Indication: Drugs for Type 2 diabetes mellitus
- Compare: rosiglitazone maleate/metformin hydrochloride vs similar drugs
- Pricing: rosiglitazone maleate/metformin hydrochloride cost, discount & access