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Rosiglitazone and Pegasys/Ribavirin
Rosiglitazone and Pegasys/Ribavirin is a Thiazolidinedione (rosiglitazone) combined with pegylated interferon alfa-2a and nucleoside analog (ribavirin) Small molecule drug developed by Beth Israel Medical Center. It is currently FDA-approved for Type 2 diabetes mellitus in patients with chronic hepatitis C infection.
This combination uses rosiglitazone to improve insulin sensitivity in diabetic patients while pegasys/ribavirin acts as an antiviral therapy for hepatitis C infection.
This combination uses rosiglitazone to improve insulin sensitivity in diabetic patients while pegasys/ribavirin acts as an antiviral therapy for hepatitis C infection. Used for Type 2 diabetes mellitus in patients with chronic hepatitis C infection.
At a glance
| Generic name | Rosiglitazone and Pegasys/Ribavirin |
|---|---|
| Sponsor | Beth Israel Medical Center |
| Drug class | Thiazolidinedione (rosiglitazone) combined with pegylated interferon alfa-2a and nucleoside analog (ribavirin) |
| Target | PPAR-γ (rosiglitazone); Interferon-α receptor and HCV NS5B polymerase (pegasys/ribavirin) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology/Diabetes and Virology/Hepatology |
| Phase | FDA-approved |
Mechanism of action
Rosiglitazone is a thiazolidinedione that activates peroxisome proliferator-activated receptor gamma (PPAR-γ) to enhance insulin sensitivity and reduce hepatic glucose production. Pegasys (peginterferon alfa-2a) combined with ribavirin provides antiviral activity against hepatitis C virus through interferon-mediated immune activation and ribavirin's direct antiviral effects. This combination addresses concurrent type 2 diabetes and chronic hepatitis C infection.
Approved indications
- Type 2 diabetes mellitus in patients with chronic hepatitis C infection
Common side effects
- Fluid retention and edema
- Weight gain
- Anemia
- Fatigue
- Flu-like symptoms
- Hepatotoxicity
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Rosiglitazone and Pegasys/Ribavirin CI brief — competitive landscape report
- Rosiglitazone and Pegasys/Ribavirin updates RSS · CI watch RSS
- Beth Israel Medical Center portfolio CI
Frequently asked questions about Rosiglitazone and Pegasys/Ribavirin
What is Rosiglitazone and Pegasys/Ribavirin?
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What is Rosiglitazone and Pegasys/Ribavirin used for?
Who makes Rosiglitazone and Pegasys/Ribavirin?
What drug class is Rosiglitazone and Pegasys/Ribavirin in?
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What does Rosiglitazone and Pegasys/Ribavirin target?
Related
- Drug class: All Thiazolidinedione (rosiglitazone) combined with pegylated interferon alfa-2a and nucleoside analog (ribavirin) drugs
- Target: All drugs targeting PPAR-γ (rosiglitazone); Interferon-α receptor and HCV NS5B polymerase (pegasys/ribavirin)
- Manufacturer: Beth Israel Medical Center — full pipeline
- Therapeutic area: All drugs in Endocrinology/Diabetes and Virology/Hepatology
- Indication: Drugs for Type 2 diabetes mellitus in patients with chronic hepatitis C infection
- Compare: Rosiglitazone and Pegasys/Ribavirin vs similar drugs
- Pricing: Rosiglitazone and Pegasys/Ribavirin cost, discount & access