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ropivicaine 0.2%
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgical procedures, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | ropivicaine 0.2% |
|---|---|
| Also known as | Naropin |
| Sponsor | University of Alabama at Birmingham |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing sodium influx and thus inhibiting depolarization. This action blocks the generation and conduction of nerve impulses in a dose-dependent manner, producing local anesthesia. It is an amide-type local anesthetic with a lower propensity for cardiotoxicity compared to bupivacaine.
Approved indications
- Local and regional anesthesia for surgical procedures
- Peripheral nerve blocks
- Epidural anesthesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies (NA)
- Erector Spinae Plane Block (ESPB): in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision. (PHASE4)
- Tap Block vs Conventional Pain Medication for Patients Undergoing Robotic Sacrocolpopexy (NA)
- Regional Block for Postoperative Free Flap Care (PHASE4)
- Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
- Comparison of Pudendal Nerve Block and Caudal Block for Hypospadias in Young Children (NA)
- Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section (PHASE4)
- Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ropivicaine 0.2% CI brief — competitive landscape report
- ropivicaine 0.2% updates RSS · CI watch RSS
- University of Alabama at Birmingham portfolio CI