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Ropivacaine with NaCl
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Ropivacaine with NaCl |
|---|---|
| Also known as | Naropin with NaCl |
| Sponsor | Corewell Health East |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia in the area of administration. The addition of sodium chloride (NaCl) maintains osmolarity and stability of the solution for injection.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural anesthesia
Common side effects
- Injection site reactions (pain, erythema)
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- Does the Common Practice of Adding Diluted Epinephrine in Tranverse Abdominal Plan Block to Ropivacaine Significantly Decrease the Peak Systemic Resorption of Ropivacaine? (NA)
- Erector Spinae Plane Block for Acute Low Back Pain (NA)
- Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery (NA)
- Intrapleural Ropivacaine Infusion in Cardiac Surgery (PHASE4)
- Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty (PHASE4)
- SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty (NA)
- PENG Block and Delirium After Hip Arthroplasty (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine with NaCl CI brief — competitive landscape report
- Ropivacaine with NaCl updates RSS · CI watch RSS
- Corewell Health East portfolio CI