Last reviewed · How we verify
Ropivacaine only
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgical procedures, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Ropivacaine only |
|---|---|
| Sponsor | University of New Mexico |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and nerve impulse transmission. This results in local anesthesia and loss of sensation in the area where it is administered. It is an amide-type local anesthetic with a long duration of action and lower cardiotoxicity compared to some other local anesthetics.
Approved indications
- Local and regional anesthesia for surgical procedures
- Peripheral nerve blocks
- Epidural anesthesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Headache
- Dizziness
- Systemic toxicity (at high doses)
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine (PHASE4)
- Does the Common Practice of Adding Diluted Epinephrine in Tranverse Abdominal Plan Block to Ropivacaine Significantly Decrease the Peak Systemic Resorption of Ropivacaine? (NA)
- Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series
- Erector Spinae Plane Block for Acute Low Back Pain (NA)
- Effects of Transversus Abdominis Plane Block on Recovery Quality and Maternal-Neonatal Outcomes After Cesarean Delivery (NA)
- Diaphragm-Sparing Regional Anesthesia Techniques for Shoulder Surgery (NA)
- Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |