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Ropivacaine + Dexmedetomidine
Ropivacaine blocks sodium channels to provide local anesthesia, while dexmedetomidine activates alpha-2 adrenergic receptors to produce sedation and analgesia.
Ropivacaine blocks sodium channels to provide local anesthesia, while dexmedetomidine activates alpha-2 adrenergic receptors to produce sedation and analgesia. Used for Regional anesthesia and analgesia for surgical procedures, Peripheral nerve blocks, Epidural and spinal anesthesia with enhanced sedation.
At a glance
| Generic name | Ropivacaine + Dexmedetomidine |
|---|---|
| Also known as | Supravlavicular Brachial Plexus Block with Ropivacaine and Dexmedetomidine, experimental, selective alpha 2 (α2) adrenergic agonist |
| Sponsor | Sahiwal medical college sahiwal |
| Drug class | Local anesthetic + alpha-2 adrenergic agonist combination |
| Target | Voltage-gated sodium channels (ropivacaine); alpha-2 adrenergic receptors (dexmedetomidine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that inhibits sodium influx in nerve fibers, preventing depolarization and conduction of nerve impulses. Dexmedetomidine is a selective alpha-2 adrenergic agonist that enhances sedation, analgesia, and anxiolysis through central nervous system effects. The combination provides enhanced regional anesthesia with improved sedation and pain control.
Approved indications
- Regional anesthesia and analgesia for surgical procedures
- Peripheral nerve blocks
- Epidural and spinal anesthesia with enhanced sedation
Common side effects
- Hypotension
- Bradycardia
- Sedation
- Dry mouth
- Dizziness
- Nausea
Key clinical trials
- Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine (PHASE4)
- PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults (NA)
- Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults (NA)
- Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- PENG Block With Dexmedetomidine in Older Adults (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
- Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine + Dexmedetomidine CI brief — competitive landscape report
- Ropivacaine + Dexmedetomidine updates RSS · CI watch RSS
- Sahiwal medical college sahiwal portfolio CI