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Ropivacaine + dexamethasone
Ropivacaine blocks sodium channels to provide local anesthesia, while dexamethasone reduces inflammation and prolongs the duration of anesthetic effect.
Ropivacaine blocks sodium channels to provide local anesthesia, while dexamethasone reduces inflammation and prolongs the duration of anesthetic effect. Used for Local and regional anesthesia for surgical procedures, Peripheral nerve blocks with prolonged analgesia.
At a glance
| Generic name | Ropivacaine + dexamethasone |
|---|---|
| Also known as | Supraclavicular Brachial Plexus Block with Ropivacaine and Dexamethasone |
| Sponsor | Sahiwal medical college sahiwal |
| Drug class | Local anesthetic with corticosteroid adjuvant |
| Target | Voltage-gated sodium channels; glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing depolarization and action potential propagation. Dexamethasone, a corticosteroid, is added to reduce perioperative inflammation and extend the duration of anesthesia by decreasing vascular uptake of the local anesthetic and modulating inflammatory mediators at the injection site.
Approved indications
- Local and regional anesthesia for surgical procedures
- Peripheral nerve blocks with prolonged analgesia
Common side effects
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Nausea
- Allergic reactions (rare)
Key clinical trials
- Erector Spinae Plane Block for Acute Low Back Pain (NA)
- The Effect of Dexamethasone Administration Route in PENG Block for Pediatric Hip Surgery (PHASE4)
- Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery (NA)
- PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults (NA)
- PENG Block Optimization: Volume and Dexamethasone Effects (PHASE4)
- Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine + dexamethasone CI brief — competitive landscape report
- Ropivacaine + dexamethasone updates RSS · CI watch RSS
- Sahiwal medical college sahiwal portfolio CI