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Ropivacaine and dexamethasone
Ropivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and prolongs the duration of the anesthetic effect.
Ropivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and prolongs the duration of the anesthetic effect. Used for Peripheral nerve blocks and local anesthesia with prolonged duration, Postoperative pain management.
At a glance
| Generic name | Ropivacaine and dexamethasone |
|---|---|
| Also known as | Noropin and adjuvant, Ropivacaine Hydrochloride Injection, Naeopin |
| Sponsor | University of Texas Southwestern Medical Center |
| Drug class | Local anesthetic with corticosteroid adjuvant |
| Target | Voltage-gated sodium channels; glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx in nerve cell membranes, preventing depolarization and nerve impulse conduction. Dexamethasone, a corticosteroid, is added to reduce local inflammation and extend the duration of anesthesia by decreasing vascular uptake of the local anesthetic and modulating inflammatory mediators at the injection site.
Approved indications
- Peripheral nerve blocks and local anesthesia with prolonged duration
- Postoperative pain management
Common side effects
- Injection site reactions
- Transient neurological symptoms
- Systemic local anesthetic toxicity (rare)
- Headache
Key clinical trials
- Erector Spinae Plane Block for Acute Low Back Pain (NA)
- The Effect of Dexamethasone Administration Route in PENG Block for Pediatric Hip Surgery (PHASE4)
- Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery (NA)
- PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults (NA)
- PENG Block Optimization: Volume and Dexamethasone Effects (PHASE4)
- Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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