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Ropivacaine 2 %
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgical procedures, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Ropivacaine 2 % |
|---|---|
| Sponsor | Hospital Ambroise Paré Paris |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and transmission of nerve impulses. This results in local anesthesia in the area where it is administered. It is an amide-type local anesthetic with a long duration of action and lower cardiotoxicity compared to some other local anesthetics.
Approved indications
- Local and regional anesthesia for surgical procedures
- Peripheral nerve blocks
- Epidural anesthesia
- Infiltration anesthesia
Common side effects
- Injection site reactions (pain, erythema)
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Nausea
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery (NA)
- The Effects of Various Concentrations of Ropivacaine on the Onset and Duration of Ankle Blocks (NA)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- Erector Spinae Plane Block for Acute Low Back Pain (NA)
- Effects of Transversus Abdominis Plane Block on Recovery Quality and Maternal-Neonatal Outcomes After Cesarean Delivery (NA)
- External Oblique Intercostal Block Versus Erector Spinae Plane Block on Postoperative Pain in Laparoscopic Radical Gastrectomy (NA)
- Diaphragm-Sparing Regional Anesthesia Techniques for Shoulder Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine 2 % CI brief — competitive landscape report
- Ropivacaine 2 % updates RSS · CI watch RSS
- Hospital Ambroise Paré Paris portfolio CI