Last reviewed 2026-04-23 · How we verify

Room air

Room air serves as a control or baseline comparator providing normal atmospheric oxygen concentration (approximately 21% O₂) for clinical trial purposes.

Room air serves as a control or baseline comparator providing normal atmospheric oxygen concentration (approximately 21% O₂) for clinical trial purposes. Used for Control/comparator arm in respiratory or oxygen-related clinical trials.

At a glance

Mechanism of action

Room air is not a pharmaceutical intervention but rather a standard environmental control used in clinical trials to establish baseline outcomes or compare against active treatments. In phase 3 trials, room air may be used as a comparator arm to evaluate the efficacy of oxygen supplementation or other respiratory interventions.

Approved indications

• Control/comparator arm in respiratory or oxygen-related clinical trials

Common side effects

No common side effects on file.

Key clinical trials

• Adenosine 2A Receptor Antagonism and AIH in ALS (PHASE1, PHASE2)
• Caracterization of the Combined Alterations in Respiration and aROUSal in Patients With Drug-resistant EpiLepsy (NA)
• Optimization of Exhaled Biomarker Collection and Analysis (NA)
• A Randomized Clinical Trial for Predictors of Successful Extubation of Pediatric Patients With or Without High Velocity Nasal Insufflation (NA)
• Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal- A Multicenter Randomized Controlled Study (NA)
• Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury (PHASE1, PHASE2)
• Combination Therapy to Improve SCI Recovery. (NA)
• Assessing Upper Extremity Function in Chronic Stroke Survivors Through Acute Intermittent Hypoxia (NA)

Primary sources

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