Last reviewed 2026-04-20 · How we verify

Rocaltrol

At a glance

Approved indications

• Hyperparathyroidism Secondary to Chronic Renal Failure
• Hypocalcemia
• Hypocalcemia from End-Stage Renal Disease with Dialysis
• Hypoparathyroidism
• Hypophosphatemia
• Plaque psoriasis
• Renal osteodystrophy

Common side effects

• Hypercalcemia
• Hypercalciuria
• Elevated serum creatinine
• Nausea
• Vomiting
• Weakness
• Headache
• Somnolence
• Dry mouth
• Constipation
• Muscle pain
• Bone pain

Serious adverse events

• Pancreatitis
• Cardiac arrhythmias
• Nephrocalcinosis
• Psychosis
• Erythema multiforme
• Allergic reaction with angioedema
• Conjunctivitis (calcific)
• Hypertension
• Ectopic calcification
• Severe erythematous skin disorders

Key clinical trials

• Effect of Local Use of Vitamin D on the Rate of Canine Distillization: a Split Mouth Randomized Control Trial (PHASE1)
• Effects of Vitamin D in Patients Undergoing Fixed Orthodontic Mechanotherapy (NA)
• Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System (PHASE1)
• Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1 (PHASE3)
• Calcitriol Monotherapy for X-Linked Hypophosphatemia (EARLY_PHASE1)
• Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction (NA)
• Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury (PHASE2)
• FGF23 Reduction : Efficacy of a New Phosphate Binder in CHronic Kidney Disease (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.