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Ringer's Lactate Crystalloid Solutions
Ringer's Lactate is a crystalloid intravenous fluid that restores intravascular volume and electrolyte balance by providing water, sodium, potassium, calcium, chloride, and lactate in physiologically balanced concentrations.
Ringer's Lactate is a crystalloid intravenous fluid that restores intravascular volume and electrolyte balance by providing water, sodium, potassium, calcium, chloride, and lactate in physiologically balanced concentrations. Used for Fluid resuscitation in hypovolemic shock, Perioperative fluid maintenance, Burn management and fluid replacement.
At a glance
| Generic name | Ringer's Lactate Crystalloid Solutions |
|---|---|
| Also known as | Fluid challenge |
| Sponsor | Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu |
| Drug class | Crystalloid intravenous solution |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Ringer's Lactate solution mimics the electrolyte composition of plasma and is used for fluid resuscitation and maintenance therapy. The lactate component is metabolized by the liver to bicarbonate, providing mild alkalinizing effects. It effectively expands the extracellular fluid compartment and restores perfusion in hypovolemic states.
Approved indications
- Fluid resuscitation in hypovolemic shock
- Perioperative fluid maintenance
- Burn management and fluid replacement
Common side effects
- Hyperchloremic acidosis
- Fluid overload/pulmonary edema
- Hypokalemia
- Phlebitis at infusion site
Key clinical trials
- Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery (PHASE1)
- Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy (PHASE2)
- Gelaspan vs Crystalloid Therapy in Sepsis (PHASE4)
- Precision Resuscitation With Crystalloids in Sepsis (NA)
- Volume Kinetics of Fluid Resuscitation in Early Sepsis
- Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PHASE3)
- Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients (NA)
- Fluids in Septic Shock (FISSH) (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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