Last reviewed 2026-04-23 · How we verify

Rifampin-free regimen

Rifampin-free regimen involves the use of rifampicin-free antitubercular drugs to treat tuberculosis.

Rifampin-free regimen involves the use of rifampicin-free antitubercular drugs to treat tuberculosis. Used for Treatment of tuberculosis in patients who are resistant to rifampin or have adverse reactions to it.

At a glance

Mechanism of action

This regimen typically includes a combination of drugs such as isoniazid, pyrazinamide, and ethambutol. The absence of rifampin allows for the treatment of patients who are resistant to rifampin or have adverse reactions to it.

Approved indications

• Treatment of tuberculosis in patients who are resistant to rifampin or have adverse reactions to it

Common side effects

• Gastrointestinal disturbances
• Hepatotoxicity
• Neuropathy

Key clinical trials

• Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (PHASE2)
• Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis (PHASE3)
• Amikacin Liposome Inhalation Suspension for Treatment of Mycobacterium Xenopi Pulmonary Infection (PHASE2)
• Four Months Moxifloxacin Containing Daily Regimen Study Among New Pulmonary Tuberculosis Patients
• Comparison Between Rifampicin and Gemifloxacin and Ciprofloxacin in Treatment of Rhinoscleroma (EARLY_PHASE1)

Primary sources

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Competitive intelligence

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