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rFSH (Gonal®,
rFSH (recombinant follicle-stimulating hormone) stimulates the growth and maturation of ovarian follicles in women undergoing fertility treatment.
rFSH (recombinant follicle-stimulating hormone) stimulates the growth and maturation of ovarian follicles in women undergoing fertility treatment. Used for Infertility in women undergoing assisted reproductive technology (ART) / in vitro fertilization (IVF), Anovulation and ovulatory disorders in women seeking fertility treatment.
At a glance
| Generic name | rFSH (Gonal®, |
|---|---|
| Sponsor | Instituto Valenciano de Infertilidad, IVI VALENCIA |
| Drug class | Gonadotropin |
| Target | FSH receptor (FSHR) |
| Modality | Small molecule |
| Therapeutic area | Reproductive Medicine / Infertility |
| Phase | FDA-approved |
Mechanism of action
rFSH is a recombinant version of the naturally occurring follicle-stimulating hormone that binds to FSH receptors on granulosa cells of ovarian follicles, promoting their development and estrogen production. This hormone is essential for controlled ovarian hyperstimulation in assisted reproductive technology (ART) procedures, enabling the retrieval of multiple mature oocytes for in vitro fertilization.
Approved indications
- Infertility in women undergoing assisted reproductive technology (ART) / in vitro fertilization (IVF)
- Anovulation and ovulatory disorders in women seeking fertility treatment
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Headache
- Injection site reactions
- Abdominal pain/bloating
- Nausea
- Mood changes