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rFSH: Follicle Stimulating Hormone
rFSH: Follicle Stimulating Hormone is a Gonadotropin Small molecule drug developed by Instituto Valenciano de Infertilidad, IVI VALENCIA. It is currently in Phase 3 development for Induction of ovulation in women with polycystic ovary syndrome (PCOS) or other ovulatory disorders, Assisted reproductive technology (ART) such as in vitro fertilization (IVF).
rFSH stimulates follicular growth and maturation in the ovaries.
rFSH stimulates follicular growth and maturation in the ovaries. Used for Induction of ovulation in women with polycystic ovary syndrome (PCOS) or other ovulatory disorders, Assisted reproductive technology (ART) such as in vitro fertilization (IVF).
At a glance
| Generic name | rFSH: Follicle Stimulating Hormone |
|---|---|
| Sponsor | Instituto Valenciano de Infertilidad, IVI VALENCIA |
| Drug class | Gonadotropin |
| Target | FSH receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive Health |
| Phase | Phase 3 |
Mechanism of action
rFSH acts by binding to the FSH receptor on the surface of granulosa cells in the ovaries, triggering a cascade of downstream effects that promote follicular growth and maturation. This ultimately leads to the release of an ovum from the ovary, making it available for fertilization.
Approved indications
- Induction of ovulation in women with polycystic ovary syndrome (PCOS) or other ovulatory disorders
- Assisted reproductive technology (ART) such as in vitro fertilization (IVF)
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Multiple pregnancy
- Headache
- Nausea and vomiting
- Abdominal pain
Key clinical trials
- Comparison of Sequential CFA vs CFA +rFSH for Elective Fertility Preservation. (PHASE3)
- rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study
- PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study (PHASE4)
- Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitary Suppression With Medroxiprogesterona Acetate (MPA) (NA)
- Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatment (NA)
- Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?
- Phase IV Study to Evaluate the Efficacy and Safety of Fang Le Shu Compared to Guo Na Fen for Controlled Ovarian Stimulation in Infertile Women Undergoing in Vitro Fertilization-embryo Transfer (IVF-ET). (PHASE4)
- Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Indian Women (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- rFSH: Follicle Stimulating Hormone CI brief — competitive landscape report
- rFSH: Follicle Stimulating Hormone updates RSS · CI watch RSS
- Instituto Valenciano de Infertilidad, IVI VALENCIA portfolio CI
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Related
- Drug class: All Gonadotropin drugs
- Target: All drugs targeting FSH receptor
- Manufacturer: Instituto Valenciano de Infertilidad, IVI VALENCIA — full pipeline
- Therapeutic area: All drugs in Reproductive Health
- Indication: Drugs for Induction of ovulation in women with polycystic ovary syndrome (PCOS) or other ovulatory disorders
- Indication: Drugs for Assisted reproductive technology (ART) such as in vitro fertilization (IVF)
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