Last reviewed 2026-04-22 · How we verify

rFSH drug dose

rFSH (recombinant follicle-stimulating hormone) stimulates the growth and maturation of ovarian follicles in women undergoing fertility treatment.

rFSH (recombinant follicle-stimulating hormone) stimulates the growth and maturation of ovarian follicles in women undergoing fertility treatment. Used for Infertility in women undergoing assisted reproductive technology (ART), Anovulation and ovulatory disorders in women.

At a glance

Mechanism of action

rFSH is a recombinant version of the naturally occurring follicle-stimulating hormone, a gonadotropin produced by the pituitary gland. It binds to FSH receptors on granulosa cells in the ovary, promoting follicular development and estrogen production. This is used in assisted reproductive technology to induce controlled ovarian hyperstimulation for egg retrieval.

Approved indications

• Infertility in women undergoing assisted reproductive technology (ART)
• Anovulation and ovulatory disorders in women

Common side effects

• Ovarian hyperstimulation syndrome (OHSS)
• Headache
• Injection site reactions
• Abdominal pain/bloating
• Nausea

Key clinical trials

• Dual Ovarian Stimulation (Duostim) and Shanghai Protocols in Poor Ovarian Responders (PHASE3)
• Randomized Controlled Trial Comparing Embryonic Quality in rFSH Versus hMG in IVF Protocol With GnRH Antagonist (PHASE4)
• Individual Versus Standard Follicle Stimulating Hormone Dose for Controlled Ovarian Stimulation and Insemination (PHASE4)

Primary sources

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